Can a bad oxygen sensor cause a cylinder misfire?

If an oxygen sensor or mass airflow sensor is failing, it could give incorrect data to your engine's computer, causing the misfire. When a vacuum line is broken, it can cause a fuel-injected motor to misfire. via

Can I run my truck without O2 sensors?

O2 sensors were introduced mainly for emissions regulation, trying to keep them as low as possible. So the answer is no, they are not absolutely needed for engines to function properly if they would designed to run without one. via

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